دوره 14، شماره 2 - ( 4-1405 )
جلد 14 شماره 2 صفحات 42-38 |
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Mohammadi S. Beyond osteogenesis and angiogenesis: The immunomodulatory role of macrophages in hAMSC-sEV-mediated repair of osteoradionecrosis of the jaw. , Jorjani Biomed J. 2026; 14 (2) :38-42
URL: http://goums.ac.ir/jorjanijournal/article-1-1138-fa.html
URL: http://goums.ac.ir/jorjanijournal/article-1-1138-fa.html
Beyond osteogenesis and angiogenesis: The immunomodulatory role of macrophages in hAMSC-sEV-mediated repair of osteoradionecrosis of the jaw. , فصلنامه علمی پژوهشی زیست پزشکی جرجانی. 1405; 14 (2) :38-42
URL: http://goums.ac.ir/jorjanijournal/article-1-1138-fa.html
چکیده: (7682 مشاهده)
Osteoradionecrosis of the jaw (ORNJ) is a severe late complication of radiotherapy driven by vascular injury, hypoxia, fibrosis, persistent inflammation, and impaired bone remodeling. A recent study demonstrated that human amniotic mesenchymal stem cell-derived small extracellular vesicles (hAMSC-sEVs) improve ORNJ repair by restoring osteogenic differentiation of irradiated bone marrow mesenchymal stem cells through PI3K/AKT signaling and enhancing endothelial angiogenic activity through Wnt/β-catenin signaling. These findings establish an important regenerative framework but leave the immune compartment largely unexplored. We propose that macrophages represent a critical mechanistic link between hAMSC-sEV therapy and coordinated tissue repair. By reprogramming radiation-dysregulated macrophages toward pro-resolving, reparative phenotypes, hAMSC-sEVs may suppress chronic inflammation while simultaneously supporting osteogenesis and neovascularization. Defining the extracellular-vesicle cargo and macrophage signaling networks responsible for this effect could advance osteoimmunology-informed strategies and improve the translational development of cell-free therapies for ORNJ. This perspective highlights priorities for experimental validation and future clinical translation.
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دریافت: 1405/1/31 | پذیرش: 1405/3/9 | انتشار: 1405/4/4
دریافت: 1405/1/31 | پذیرش: 1405/3/9 | انتشار: 1405/4/4
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